The world's first AI-designed DNA COVID vaccine was tested in humans, and the coverage frames it as alarming and under-tested.

Jun 12, 2026

A small UK trial of an AI-formulated DNA COVID vaccine is being sold as "safe and well tolerated," but critics say the safety claims are thin.

  • The vaccine was tested on only 39 people, with follow-up for six months and no public list of side effects — just a claim that none were serious.
  • Instead of mRNA, it uses small loops of DNA shot into the skin with an air-gun device rather than a needle.
  • The big worry is that some of that DNA could get absorbed into a person's own genes, and the makers admit they did not actually test for this.
  • The AI was used to find the part of the virus that stays the same across variants, so one shot could target many related bat and animal coronaviruses.
  • One trial participant caught COVID anyway, raising doubts about whether it even works.

Outlook: Expect more DNA-based vaccines to move forward as the industry shifts away from mRNA, with safety testing likely to stay a flashpoint.

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